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Gene expression analysis uncovered that ACKR3 is highly expressed in several brain areas similar to crucial opioid activity centers. Also, its expression concentrations are sometimes bigger than Individuals of classical opioid receptors, which additional supports the physiological relevance of its noticed in vitro opioid peptide scavenging ability.
Over and above its pain-relieving consequences, conolidine has shown a good protection margin in preclinical toxicology assessments. Unlike opioids, which often trigger respiratory melancholy at higher doses, conolidine has not generated indications of significant respiratory suppression. On top of that, behavioral assessments in murine models sugg